1.

Andréa LeBlanc, Hui Liu, Cynthia Goodyer, Catherine Bergeron, Jennifer Hammond*. Caspase-6 alters amyloid precursor protein metabolism in apoptotic human neurons and is expressed and activated in Alzheimer's Disease. J. Biol. Chem. 274, 1999 23426-23436.

2.

Yan Zhang, Cynthia Goodyer, and Andréa LeBlancÝSelective and prolonged apoptosis in human primary neurons microinjected with active caspase-3, 6, 7 and 8. J. Neurosci. 20 (22),2000: 8384-8389.

3.

Jennifer Hammond, Quynh Le, Cindy Goodyer, Morie Gelfand, Mark Trifiro, Andrea LeBlanc. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. J. Neurochem. 77, 1-9, 2001.

4.

Yan Zhang, Omar Tounekti, Beverly Akerman, Cynthia G. Goodyer, and Andréa LeBlanc. 17-ß-Estradiol induces an inhibitor of active caspases. J. Neurosci. 21:RC176, 1-6, 2001.

5.

Younes Bounhar and Yan Zhang (first co-authors), Cynthia Goodyer, Andrea LeBlanc. Prion protein protects human neurons against Bax-mediated apoptosis. J. Biol. Chem 2001 , 276, 39145-39149.

6.

Yan Zhang*Ý, Richard McLaughlinfΦ, Cynthia Goodyerý, and Andréa LeBlanc*Ý.Selective Cytotoxicity of Intracellular Amyloid ß Peptide1-42 through p53 and Bax in Cultured Primary Human Neurons. J. Cell Biol. 2002, 156 (3), 519-529. Featured in News.

7.

Neuromethods: Apoptosis Techniques and Protocols, second edition, edited by Andrea LeBlanc, Series Editor, G. Baker and A. Boulton, Humana Press, 2002,

8.

Megan Blacker, Mark C. Noe, Thomas J. Carty, Cynthia G. Goodyer, Andrea C. LeBlanc. TACE inhibitor prevents regulated secretion of amyloid precursor protein without altering amyloid ß peptide production in human neurons. J. Neurochem. 83(6) 2002, 1349-1357.

9.

Yan Zhang, Yanguo Hong, Younes Bounhar, Emily Vereker, Xavier Roucou, Megan Blacker, Omar Tounekti, William J. Bowers, Howard J. Federoff, Cynthia G. Goodyer, Andréa LeBlanc. p75NTR protects primary cultures of human neurons against extracellular amyloid ß-peptide cytotoxicity. J. Neurosci. 2003, 23: 7385-7394.

10.

Andrea LeBlanc and Xavier Roucou. The perspective “A view form the top. Science, 301, 2003, 168-169.

11.

*Xavier Roucou, Qi Guo, Yan Zhang, Cynthia G. Goodyer and Andréa C. LeBlanc. Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. J. Biol. Chem. 278, 2003, 40877-40881.

12.

Roucou, X., Gains, M. LeBlanc, A. The Neuroprotective Functions of Prion Protein. J. Neurosci. Res. 75, 2004, 153-161.

13.

Omar Tounekti, Yan Zhang, Cynthia G. Goodyer, and Andréa LeBlanc. Proteasomal degradation of caspase-6 in 17ß-estradiol-treated neurons. J. Neurochem. 2004 89(3):561-8.

14.

Huishan Guo, Steffen Albrecht, Martine Bourdeau, Tracy Petzke, Catherine Bergeron and Andrea C. LeBlanc. Active Caspase-6 and Caspase-6 cleaved Tau in neuropil threads, senile plaque associated neurites and neurofibrillary tangles in Alzheimer’s Disease. Am. J. Pathol. 2004, 165: 523-531 (Commentary by Cribbs et al., Am. J. Pathol., 165, 2004, 353-355).

15.

Yan Zhang, Nathalie Champagne, Lenore Beitel, Cynthia Goodyer, Mark Trifiro and Andréa LeBlanc. Estrogen and androgens protection of human neurons against intracellular Aß1-42 toxicity through Hsp70. J. Neurosci. 2004 24: 5315 – 5321.

16.

Xavier Roucou and Andrea LeBlanc. Cellular Prion Protein Neuroprotective Function: Implications in Prion Diseases. J. Mol. Med. 2005 83(1) p3-11.

Accepted / In press Refereed Papers

1.

LeBlanc AC (2005) The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death. Current Alzheimer Research 2005 (in press).

2.

Xavier Roucou, Yan Zhang, Cynthia G. Goodyer, and Andrea LeBlanc. The cellular prion protein suppresses Bax activation in human primary neurons. Cell Death and Differentiation. 2005 (in press: E-pub).

Investigateurs
  

Dre Chantal Autexier
Dr Howard Bergman
Dr Howard Chertkow
Dr Gustavo Duque
Dre Andrea LeBlanc

Dr Hemant Paudel
Dr Stéphane Richard
Dr Uri Saragovi
Dr Hyman Schipper
Dre Eugenia Wang